In Vivo Antimalarial Activity of the Leaf Extract of Osyris quadripartita Salzm. ex Decne and Its Major Compound (–) Catechin

Table 1

Percentage suppression and mean survival time of Plasmodium berghei-infected mice after administration of 80% methanol leaf extract of Osyris quadripartita and its constituent (−) catechin.

Treatment	Dose (mg/kg, p.o)	% Parasitemia ± SEM	% Suppression	Survival time (in days) ± SEM
Vehicle	0.5 ml	49.00 ± 1.92	0.00^a	5.60 ± 0.40^a
Leaf extract	100	22.20 ± 1.15	54.69^b	10.80 ± 0.37^b
	200	18.60 ± 0.92	62.04^b,c	14.00 ± 0.70^c
	400	14.40 ± 1.12	70.61^c	14.60 ± 0.51^c
(–) Catechin	100	27.60 ± 0.24	42.55^d	10.60 ± 0.51^d
	200	21.40 ± 0.51	54.47^e	11.80 ± 0.66^d
	400	16.80 ± 0.37	64.26^f	12.60 ± 0.51^d
Chloroquine	25	0.20 ± 0.19	99.60^g	30.20 ± 1.77^e

Note. Values are presented as mean ± SEM; n = 5; means followed by a different letter indicate significant differences between different doses of the same treatments, vehicle, and positive control in the same column ().