In Vivo Antimalarial Activity of the Leaf Extract of Osyris quadripartita Salzm. ex Decne and Its Major Compound (–) Catechin

Table 2

Body weight of Plasmodium berghei-infected mice after administration of the 80% methanol leaf extract of Osyris quadripartita and (−) catechin.

Treatment	Dose (mg/kg, p.o)	Wt.(g) D0 ± SEM	Wt.(g) D4 ± SEM	Weight change
Vehicle	0.5 ml	24.80 ± 1.50	23.00 ± 1.73	−7.26^a
Leaf extract	100	27.20 ± 0.80	28.20 ± 0.73	3.70^b
	200	24.80 ± 0.86	26.20 ± 0.86	5.60^b
	400	25.00 ± 0.55	26.00 ± 0.55	4.00^b
(–) Catechin	100	22.80 ± 0.97	23.80 ± 0.66	4.39^c
	200	23.00 ± 1.00	23.60 ± 0.60	2.61^c
	400	22.00 ± 1.58	23.20 ± 1.24	5.45^c
Chloroquine	25	29.20 ± 1.39	31.80 ± 1.36	8.90^d

Note. Values are presented as mean ± SEM; n = 5; means followed by a different letter indicate significant differences between different doses of the same treatments, vehicle, and positive control in the same column ().