Effect of Ketorolac on Pharmacokinetics and Pharmacodynamics of 5-Fluorouracil: In Vivo and In Vitro Study

Table 1

Plasma concentration of 5-FU (50 mg/kg, i.p) in the control group and the pretreatment group as mean ± SD ().

Time (min)	Mean ± STDEV plasma concentration of 5-FU (µg/ml)
	Control group (5-FU alone)	Pretreatment group (5-FU + ketorolac)
0	0	0
5	2.39 ± 0.45	2.67 ± 1.38
15	4.74 ± 0.63	4.79 ± 1.21
30	6.31 ± 0.59	7.29 ± 3.16
60	3.28 ± 0.55	10.28 ± 2.31
120	2.04 ± 0.24	9.58 ± 1.40
240	0.72 ± 0.17	3.15 ± 0.77