Effect of Ketorolac on Pharmacokinetics and Pharmacodynamics of 5-Fluorouracil: In Vivo and In Vitro Study

Table 2

Pharmacokinetic parameters of 5-FU (50 mg/kg, i.p) in the control group and the pretreatment group as mean ± SD.

Parameter	Control group (5-FU alone)	Pretreatment group (ketorolac + 5-FU)
Ka (1/min)	0.046 ± 0.002	0.023 ± 0.011
K10 (1/min)	0.018 ± 0.001	0.01 ± 0.002
K12 (1/min)	0.019 ± 0.001	1.81E-10 ± 1.3E-10
K21 (1/min)	0.011 ± 0.001	0.005 ± 0.002
T 1/2Alpha (min)	15.99 ± 0.67	74.44 ± 14.66
T 1/2Beta (min)	153 ± 8	145 ± 58
T 1/2ka (min)	14.95 ± 0.63	37.3 ± 18.1
V/F ((mg/kg)/(μg/ml))	3.74 ± 0.41	2.54 ± 0.89
CL/F ((mg/kg)/(μg/ml)/min)	0.068 ± 0.011	0.023 ± 0.005
T max (min)	25.65 ± 0.52	69.95 ± 13.77
C max (μg/ml)	5.69 ± 0.68	10.39 ± 1.49
AUC 0–240 (μg/ml.min)	568 ± 78	1750 ± 280
AUC 0-inf (μg/ml.min)	750 ± 115	2206 ± 374
AUMC (μg/ml.min^2)	130199 ± 24878	356887 ± 70025