The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects

Table 3

Anticancer agent that shows chemotherapeutic properties on various cell lines.

Name of the compound	Source	Name of the source	Mechanism of action	Activity against cell line	Reference
4-Ipomeanol	Plant	Ipomoeca batatas	Inhibits DNA topoisomerase I and induces delay in the cell cycle at gap G-1 phase or S phase	Induces cell death in human carcinoma including breast, ovary, lung, and colon carcinoma cells	[54, 68]
Alvaradoin E (10)	Plant	Alvaradoa haitiensis Urb	—	Antileukemic activity; KB, LNcaP, and CoI2 cells	[69, 70]
Laulimalide and Isolanulide	Marine	Hyatella sp	Microtubule—stabilizing agent—inhibited the P-glycoprotein responsible for multiple drug resistance in tumor cells	Cytotoxic against KB cell line	[71]
5-Episinuleptolide acetate	Marine	Sinularia sp	—	Cytotoxic against cell lines like K562, Molt 4, and HL 60.	[38]
Secosterol	Marine	Lobophytum sp	—	Antitumor and antileukemic against human ovarian tumor and human leukemia cell lines	[72, 73]
Fucoidan-sulfated polysaccharide	Marine	Brown algae	Activation of the host immune responses	Effective against apoptosis, human lymphoma, and HS-Sultan cell line	[74]
Halomon pentahalogenated	Marine	Portieria hornemannii	Acts as demethylating agent	Cytotoxic cancer cell line	[75, 76]
Polyunsaturated aldehydes (PUAs)	Marine diatoms	Thalassiosira rotula, S. costatum, and P. delicatissima	—	Anticancer against human colon adenocarcinoma cell line	[77]