Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model

Figure 4

Histopathological examination of rat liver from control group (a), diseased control (b), standard drug treated (c), MEOAA (250 and 500 mg/kg) treated groups (d and e) in paracetamol-induced hepatotoxicity. (a) Control group showed normal hepatic architecture. No inflammation, hydropic degeneration, fibrosis, necrosis, atypia, steatosis, or malignancy were seen, (b) diseased rat liver revealed gross hydropic degeneration, steatosis, and necrosis of hepatocytes. However, some areas showed periportal fibrosis with adjacent aggregates of lymphocytes with neutrophilic inflammation, (c) standard drug-treated group showed near to normal parenchymal architecture of hepatic plates with some areas of hepatocytic vacuolation. No atypia and malignancy was seen, (d) MEOAA (250 mg/kg) treatment showed mild degeneration of hepatocytes and central veins dilation. Sinusoids were dilated and congested. Liver tissue showed apoptotic changes. No atypia and malignancy was seen, (e) MEOAA (500 mg/kg) treatment represents normal hepatic architecture. Regeneration of hepatic cells was observed. No atypia or malignancy was seen.

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