Journal of Tropical Medicine

Research Article

Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal

Table 1

Hematological and biochemical findings in study participants.


Parameters	Dengue negative (n = 171)	Dengue positive (n = 177)	value^†
Parameters	Median (Q₃–Q₁)	Median (Q₃–Q₁)	value^†

Age (years)	30.0 (45.0–21.0)	37.0 (55.0–24.0)	0.006
Hemoglobin (gm/dl)	13.8 (15.03–13.35)	14.4 (15.67–12.89)	ns
RBC (X 10¹²/L)	4.65 (5.01–4.31)	4.79 (5.19–4.43)	ns
HCT (%)	40.0 (43.5–37.9)	40.7 (44.15–36.65)	ns
MCV (fl)	86.0 (89.0–83.0)	84.9 (88.25–81.3)	0.041
MCH (pg)	30.1 (31–28.8)	30.0 (82.55–31.30)	ns
MCHC (gm/dl)	35 (35.2–34.0)	35.5 (36–35.2)	<0.001
TLC (cells per µl)	6500 (7500–5370)	3880 (5790–2950)	<0.001
Neutrophil (%)	64 (69–58)	67 (76–59)	ns
Lymphocyte (%)	27 (32–23)	21 (30–14)	ns
Monocyte (%)	7 (8–5)	9 (13–7)	<0.001
Eosinophil (%)	2 (3–1)	1 (2–1)	<0.001
Platelets (per µl)	286000 (336000–223000)	164000 (192000–127000)	<0.001
NLR	2.37 (2.91–1.8)	3.37 (5.61–1.96)	ns
LMR	4.29 (5.5–3.5)	2.57 (3.78–1.46)	<0.001
Glucose (mg/dl)	87.66 (111.24–73.08)	98.1 (117–86.0)	<0.001
Urea (mg/dl)	23.34 (31.26–20.74)	21.78 (27.24–17.1)	ns
Creatinine (mg/dl)	0.84 (0.95–0.73)	0.92 (1.17–0.76)	ns
Total bilirubin (mg/dl)	0.48 (0.58–0.45)	0.50 (0.65–0.40)	0.009
Direct bilirubin (mg/dl)	0.11 (0.14–0.05)	0.10 (0.12–0.86)	ns
Total protein (gm/dl)	6.9 (7.3–6.4)	7.06 (7.38–6.65)	0.006
Albumin (gm/dl)	4.2 (4.8–3.9)	4.03 (4.32–3.7)	<0.001
ALP (U/L)	145 (169–105)	73.77 (129.6–61.07)	<0.001
AST (U/L)	25 (28–21)	37.51 (56.23–28.06)	<0.001
ALT (U/L)	29 (38–24)	30.64 (48.7–17.47)	<0.001
AST/ALT ratio	0.82 (0.93–0.72)	1.29 (1.73–1.02)	<0.001

RBC, red blood cell; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; TLC, total leukocyte count; NLR, neutrophil lymphocyte ratio; LMR, lymphocyte monocyte ratio; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ns, nonsignificant; value <0.05 is considered significant. † signifies analysis via Mann–Whitney U test. The bold numerical values in the table represent statistical significance.