Journal of Tropical Medicine

Research Article

Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal

Table 3

Kruskal–Wallis test and the post hoc Dunn’s pairwise analysis with Bonferroni adjustment among the dengue negative group and NS1 positive, IgM positive, and both NS1 + IgM positive dengue patients.


Parameters	Kruskal–Wallis test		Dunn’s pairwise comparison with Bonferroni adjustment
	Dengue positive (NS1, NS1 + IgM (B), IgM)		value
	Dengue negative (C)		value
	H	value	NS1/C	B/C	IgM/C	B/IgM	B/NS1	NS1/IgM

Age (yrs)	7.949	0.047	ns	ns	ns	ns	ns	ns
Hemoglobin (gm/dl)	7.491	ns	—	—	—	—	—	—
RBC (X 10¹²/L)	2.756	ns	—	—	—	—	—	—
HCT (%)	2.923	ns	—	—	—	—	—	—
MCV (fl)	11.721	0.008	ns	ns	0.013	ns	ns	0.044
MCH (pg)	21.988	<0.001	ns	ns	0.04	ns	ns	<0.001
MCHC (gm/dl)	54.099	<0.001	<0.001	0.024	ns	ns	ns	<0.001
TLC (cells per µl)	116.280	<0.001	<0.001	<0.001	<0.001	0.004	ns	ns
Neutrophil (%)	22.970	<0.001	ns	0.035	ns	ns	<0.001	<0.001
Lymphocyte (%)	29.998	<0.001	<0.001	ns	ns	ns	<0.001	<0.001
Monocyte (%)	47.874	<0.001	<0.001	<0.001	ns	ns	ns	ns
Eosinophil (%)	51.000	<0.001	<0.001	ns	<0.001	ns	0.002	ns
Platelets (per µl)	193.996	<0.001	<0.001	<0.001	<0.001	ns	ns	ns
NLR	28.772	<0.001	0.002	ns	ns	ns	<0.001	<0.001
LMR	65.861	<0.001	<0.001	0.001	ns	ns	ns	<0.001
Glucose (mg/dl)	45.213	<0.001	0.012	<0.001	<0.001	ns	ns	0.016
Urea (mg/dl)	17.610	0.001	ns	0.035	ns	0.012	ns	<0.001
Creatinine (mg/dl)	10.893	0.012	0.016	ns	ns	0.046	ns	ns
Total bilirubin (mg/dl)	7.939	0.047	ns	ns	ns	ns	ns	ns
Direct bilirubin (mg/dl)	2.015	ns	—	—	—	—	—	—
Total protein (gm/dl)	12.869	0.005	ns	0.003	ns	ns	ns	ns
Albumin (gm/dl)	1.859	0.002	0.002	ns	ns	ns	ns	ns
ALP (U/L)	38.872	<0.001	<0.001	ns	ns	ns	0.011	<0.001
AST (U/L)	166.520	<0.001	<0.001	<0.001	<0.001	ns	0.013	0.008
ALT (U/L)	80.633	<0.001	ns	<0.001	<0.001	<0.001	ns	<0.001
AST/ALT ratio	105.156	<0.001	<0.001	<0.001	<0.001	ns	ns	ns

RBC, red blood bell; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; TLC, total leukocyte count; NLR neutrophil lymphocyte ratio; LMR, lymphocyte monocyte ratio; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ns, nonsignificant; is considered significant. The bold numerical values in the table represent statistical significance.