Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal

Table 4

Binary logistic regression analysis for laboratory parameters in overall dengue-positive study participants.

Parameter	Univariate analysis		Multivariate analysis
	ORC (95% CI)	value	ORA (95% CI)	value
MCHC	1.615 (1.290–2.023)	<0.001	ns	ns
Platelet	1.000 (1.000–1.000)	<0.001	1.000 (1.000–1.000)	<0.001
TLC	0.999 (0.999–1.000)	<0.001	1.000 (0.999–1.000)	0.002
Neutrophil	0.983 (0.966 1.001)	0.064	ns	ns
Lymphocyte	1.003 (0.982–1.023)	0.804	—	—
Monocytes	1.319 (1.213–1.434)	<0.001	ns	ns
LMR	0.879 (0.798–0.968)	0.009	ns	ns
Glucose	1.026 (1.017–1.035)	<0.001	1.034 (1.009–1.061)	0.008
Total protein	1.584 (1.080–2.325)	0.019	ns	ns
Albumin	0.505 (0.326–0.780)	0.002	ns	ns
ALT	1.044 (1.030–1.059)	<0.001	ns	ns
AST	1.159 (1.113–1.207)	<0.001	1.129 (1.050–1.214)	0.001
ALP	0.997 (0.993–1.000)	0.056	ns	ns
AST/ALT	18.902 (8.759–40.793)	<0.001	ns	ns

RBC, red blood cell; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; TLC, total leukocyte count; NLR, neutrophil lymphocyte ratio; LMR, lymphocyte monocyte ratio; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; OR_C, crude odds ratio; OR_A, adjusted odds ratio. In univariate logistics, was considered statistically significant. In multivariate analysis, was considered statistically significant. The bold numerical values in the table represent statistical significance.