Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal

Table 5

Univariate logistic regression analysis for laboratory parameters in the NS1-only, both NS1 + IgM, and IgM-only positive dengue patients.

Univariate logistics
Parameters	NS1 only		Both NS1 + IgM		IgM only
	ORC (95% CI)	value	ORC (95% CI)	value	ORC (95% CI)	value
MCHC	2.768 (1.943–3.943)	<0.001	1.464 (1.028–2.085)	0.035	0.997 (0.732–1.357)	0.983
Platelet	1.000 (1.000–1.000)	<0.001	1.000 (1.000–1.000)	<0.001	1.000 (1.000–1.000)	<0.001
TLC	0.999 (0.999–1.000)	<0.001	0.999 (0.999–0.999)	<0.001	1.000 (1.000–1.000)	0.022
Neutrophil	1.023 (0.998–1.049)	0.075	0.949 (0.924–0.976)	<0.001	0.956 (0.930–0.983)	0.001
Lymphocyte	0.945 (0.916–0.975)	<0.001	1.039 (1.007–1.072)	0.017	1.049 (1.018–1.082)	0.002
Monocytes	1.346 (1.225–1.479)	<0.001	1.389 (1.250–2.543)	<0.001	1.218 (1.093–1.358)	<0.001
LMR	0.5240 (0.426–0.645)	<0.001	0.846 (0.715–1.002)	0.052	1.044 (0.969–1.126)	0.256
Glucose	1.019 (1.009–1.029)	<0.001	1.033 (1.023–1.044)	<0.001	1.034 (1.023–1.045	<0.001
Total protein	1.415 (0.878–2.279)	0.154	2.645 (1.434–4.879)	0.002	1.209 (0.676–2.159)	0.522
Albumin	0.464 (0.268–0.806)	0.006	0.645 (0.338–1.232)	0.184	0.451 (0.229–0.885)	0.021
ALT	1.035 (1.020–1.051)	<0.001	1.053 (1.037–1.069)	<0.001	1.055 (1.039–1.071)	<0.001
AST	1.153 (1.108–1.201)	<0.001	1.168 (1.121–1.216)	<0.001	1.169 (1.123–1.218)	<0.001
ALP	0.988 (0.982–0.993)	<0.001	1.002 (0.997–1.007)	0.552	1.002 (0.998–1.007)	0.323
AST/ALT	21.338 (9.386–8.510)	<0.001	21.221 (8.782–51.280)	<0.001	14.106 (5.777–34.006)	<0.001

RBC, red blood cell; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; TLC, total leukocyte count; NLR, neutrophil lymphocyte ratio; LMR, lymphocyte monocyte ratio; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; OR_C, crude odds ratio; OR_A, adjusted odds ratio; was considered statistically significant. The bold numerical values in the table represent statistical significance.