Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal

Table 6

Multinomial multivariate logistic regression analysis for laboratory parameters in NS1, both NS1 + IgM, and IgM positive dengue patients with the dengue negative group as reference.

Multivariate logistics
	NS1 only		Both NS1 + IgM		IgM only
Parameters	ORA (95% CI)	value	ORA (95% CI)	value	ORA (95% CI)	value
MCHC	ns	ns	ns	ns	—	—
Platelets	1.000 (1.000–1.000)	0.006	1.000 (1.000–1.000)	<0.001	1.000 (1.000–1.000)	0.001
TLC	0.999 (0.999–1.000)	<0.001	0.999 (0.999–1.000)	<0.001	ns	ns
Neutrophil	ns	ns	ns	ns	ns	ns
Lymphocyte	ns	ns	0.520 (0.306–0.884)	0.016	ns	ns
Monocyte	2.332 (1.140–4.771)	0.020	ns	ns	ns	ns
LMR	ns	ns	ns	ns	—	—
Glucose	1.028 (1.003–1.055)	0.029	1.031 (1.006–1.057)	0.017	1.037 (1.012–1.062)	0.004
Total protein	ns	ns	ns	ns	—	—
Albumin	ns	ns	ns	ns	ns	ns
ALT	ns	ns	ns	ns	ns	ns
AST	1.131 (1.050–1.218)	0.001	1.136 (1.056–1.222)	<0.001	1.141 (1.063–1.225)	<0.001
ALP	ns	ns	—	—	—	—
AST/ALT	ns	ns	ns	ns	ns	ns

RBC, red blood cell; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; TLC, total leukocyte count; NLR neutrophil lymphocyte ratio; LMR, lymphocyte monocyte ratio; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; OR_C, crude odds ratio; OR_A, adjusted odds ratio; was considered statistically significant. The bold numerical values in the table represent statistical significance.