Association of Hematological and Biochemical Parameters with Serological Markers of Acute Dengue Infection during the 2022 Dengue Outbreak in Nepal
Table 7
AUROC of laboratory parameters in overall positive, NS1 only, NS1 + IgM, and IgM only-positive dengue patients.
Dengue positive
Parameters
AUC
S.E.
value
95% CI
Cut-off
Sensitivity (%)
Specificity (%)
Overall
Platelets
0.924
0.014
<0.001
0.897–0.951
200000
83.6
83.6
TLC
0.817
0.023
<0.001
0.771–0.862
5440
75.1
74.9
AST
0.882
0.019
<0.001
0.845–0.919
29.21
80.8
83.0
Glucose
0.686
0.028
<0.001
0.630–0.741
95.16
62.7
62.6
NS1 only
Platelets
0.701
0.027
<0.001
0.648–0.755
179000
65.1
65.7
TLC
0.685
0.035
<0.001
0.617–0.752
4995
63.9
63.8
AST
0.631
0.032
<0.001
0.568–0.694
32.30
63.9
63.4
Glucose
0.533
0.035
0.357
0.465–0.602
96.75
53.0
53.6
Both NS1 + IgM
Platelets
0.832
0.026
<0.001
0.781–0.884
154000
76.1
76.8
TLC
0.814
0.030
<0.001
0.754–0.874
4304
73.9
75.8
AST
0.803
0.031
<0.001
0.743–0.863
43.21
76.1
76.2
Glucose
0.632
0.046
0.004
0.542–0.721
101.43
58.7
58.6
IgM only
Platelets
0.764
0.038
<0.001
0.688–0.839
166500
70.8
71.0
TLC
0.581
0.046
0.073
0.491–0.670
4995
58.3
59.7
AST
0.811
0.038
<0.001
0.735–0.886
39.43
75.0
75.0
Glucose
0.712
0.044
<0.001
0.625–0.788
103.25
62.5
62.7
TLC, total leukocyte count; AST, aspartate aminotransferase; AUC was interpreted as follows: 0.5 to 0.6, unsatisfactory; 0.6 to 0.7, satisfactory; 0.7 to 0.8, good; 0.8 to 0.9, very good; and >0.9, excellent.
