Evaluation of the Inhibitory Effect of Moringa oleifera Leaves Methanolic Extract against In Vitro Growth of Several Babesia Species and Theileria equi and the In Vivo Growth of Babesia microti
Table 2
Growth inhibitory efficacy of Moringa oleifera leaves/diminazene aceturate combinations on bovine Babesia and equine Babesia and Theileria infections.
Group
Fluorescence values (mean ± SD)
B. bovis
B. bigemina
T. equi
B. caballi
Control
253.07 ± 5.09
223.62 ± 1.37
311.95 ± 9.79
296.04 ± 1.88
DA IC50
115.50 ± 0.17
117.92 ± 2.66
149.45 ± 0.21
126.63 ± 0.49
M1 (3/4 : 3/4)
16.78 ± 0.63
115.90 ± 5.57
1.04 ± 1.14
71.02 ± 0.57
M2 (3/4 : 1/2)
27.91 ± 0.09
150.28 ± 3.10
7.64 ± 1.15
86.92 ± 0.31
M3 (1/2 : 3/4)
27.32 ± 0.28
159.27 ± 1.53
13.64 ± 0.83
89.12 ± 0.29
M4 (1/2 : 1/2)
27.97 ± 0.44
160.87 ± 2.38
15.48 ± 0.83
89.85 ± 1.10
M5 (1/4 : ¾)
70.56 ± 0.41
171.57 ± 1.72
19.14 ± 0.58
91.79 ± 0.69
M6 (1/4 : 1/2)
95.48 ± 1.85
194.73 ± 2.54
21.36 ± 0.83
97.85 ± 1.31
M7 (1/8 : 3/4)
142.13 ± 1.37
199.22 ± 0.55
36.29 ± 1.36
114.99 ± 1.70
M8 (1/8 : 1/2)
150.31 ± 1.62
202.10 ± 1.06
36.19 ± 0.24
115.05 ± 3.45
statistically significant differences between the mixed-drug-treated and control groups only. statistically significant differences between the mixed-drug-treated group and both the diminazen aceturate and control groups. M1–8 refer to the combinations of Moringa oleifera leaves (MOL): DA, diminazen aceturate.
