Evaluation of the Inhibitory Effect of Moringa oleifera Leaves Methanolic Extract against In Vitro Growth of Several Babesia Species and Theileria equi and the In Vivo Growth of Babesia microti
Table 3
Growth inhibitory efficacy of Moringa oleifera leaves and highly potent MMV compounds combinations on B. bovis infection.
Group
Fluorescence values (mean ± SD)
MMV compounds
MMV665941
MMV396693
MMV006787
MMV665810
MMV007092
MMV085203
MMV666093
MMV665875
Control
260.31 ± 2.68
MMV IC50
114.18 ± 2.42
124.09 ± 1.44
133.49 ± 4.16
117.51 ± 3.01
129.22 ± 3.06
115.27 ± 2.18
122.88 ± 4.57
128.03 ± 5.77
M1 (3/4 : 1/2)
13.31 ± 0.24
18.02 ± 0.71
12.07 ± 1.62
14.70 ± 1.23
22.56 ± 0.39
23.95 ± 0.32
9.09 ± 0.36
11.54 ± 1.05
M2 (3/4 : 1/8)
30.21 ± 0.27
27.99 ± 0.58
25.43 ± 2.48
20.19 ± 3.22
34.12 ± 1.47
35.99 ± 0.82
21.77 ± 4.51
13.85 ± 0.81
M3 (1/2 : 1/2)
48.12 ± 6.63
114.05 ± 2.43
91.00 ± 0.25
96.90 ± 6.26
72.25 ± 0.48
121.17 ± 1.51
84.73 ± 0.64
23.80 ± 0.65
M4 (1/2 : 1/8)
109.23 ± 1.57
117.59 ± 0.42
156.23 ± 6.36
100.55 ± 0.32
116.81 ± 2.59
133.47 ± 0.28
102.63 ± 0.07
25.98 ± 1.09
M5 (1/4 : 1/2)
113.83 ± 2.11
165.22 ± 0.10
158.00 ± 2.79
121.70 ± 0.32
123.69 ± 2.14
172.62 ± 1.84
152.17 ± 0.21
40.92 ± 0.54
M6 (1/4 : 1/8)
127.75 ± 2.50
176.15 ± 1.04
168.15 ± 3.01
124.13 ± 0.28
138.29 ± 0.40
201.90 ± 0.78
163.78 ± 1.34
66.44 ± 0.77
M7 (1/8 : 1/2)
130.85 ± 0.92
177.29 ± 0.67
184.13 ± 0.42
170.58 ± 0.71
137.40 ± 0.46
203.00 ± 3.98
161.35 ± 0.04
83.30 ± 1.11
M8 (1/8 : 1/8)
163.58 ± 2.9
177.77 ± 3.52
187.85 ± 1.59
175.28 ± 0.21
158.70 ± 0.71
210.12 ± 1.31
187.58 ± 1.06
102.92 ± 1.17
statistically significant differences between the mixed-drug-treated group and the control group. statistically significant differences between the mixed-drug-treated group and both MMV hits-treated groups and the control group. M1–8 refer to the mixtures of MOL: MMV compounds.
