Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

Table 2

Meta-analysis results of the association between SNPs in UGT1A1/UGT2B7 and AT-DILI risk under the allele model.

Genes	Country	SNPs	Study numbers	Heterogeneity test			Overall effect
				χ^2		I^2	OR (95% CI)
UGT1A1	All	rs4148323 (G> A)	5	5.64	0.228	29	0.983 (0.811–1.191)	0.857
	All	rs2003569 (G> A)	2	0.00	0.993	0	0.989 (0.784–1.247)	0.923
	All	rs8330 (C > G)	2	0.44	0.506	0	0.852 (0.681–1.065)	0.159
	All	rs4148328 (T > C)	2	5.66	0.017	82	0.988 (0.711–1.375)	0.945
	All	rs3755319 (A > C)	2	0.66	0.415	0	1.044 (0.852–1.280)	0.677
	China	rs4148323 (G> A)	4	5.40	0.145	44	0.982 (0.777–1.242)	0.881
UGT2B7	China	rs7662029 (A > G)	2	0.01	0.938	0	1.547 (1.249–1.917)	<0.001
	China	rs7439366 (T > C)	2	0.23	0.632	0	0.585 (0.477–0.717)	<0.001

UGT1A1, UDP-glucuronosyltransferase 1A1; UGT2B7, UDP-glucuronosyltransferase 2B7; AT-DILI, antituberculosis drug-induced liver injury; SNPs, single nucleotide polymorphisms; OR, odds ratio; 95% CI, 95% confidence interval.