Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

Table 3

Meta-analysis results of the association between SNPs in UGT1A1/UGT2B7 and AT-DILI risk under different genetic models.

Genes	Country	SNPs	Study numbers	Dominant model					Recessive model					Homozygote model					Heterozygote model
				Heterogeneity test			Overall effect		Heterogeneity test			Overall effect		Heterogeneity test			Overall effect		Heterogeneity test			Overall effect
				χ^2		I^2	OR (95% CI)		χ^2		I^2	OR (95% CI)		χ^2		I^2	OR (95% CI)		χ^2		I^2	OR (95% CI)
UGT1A1	All	rs4148323 (G> A)	5	4.24	0.374	6	0.989 (0.824–1.188)	0.909	5.55	0.238	28	0.775 (0.432–1.391)	0.393	5.97	0.204	33	0.780 (0.419–1.452)	0.433	3.03	0.552	0	1.017 (0.851–1.216)	0.852
	All	rs2003569 (G> A)	2	0.00	1.000	0	0.970 (0.740–1.272)	0.824	0.01	0.929	0	1.090 (0.574–2.070)	0.793	0.01	0.927	0	1.075 (0.562–2.054)	0.828	0.00	0.994	0	0.956 (0.720–1.269)	0.756
	All	rs8330 (C > G)	2	0.71	0.399	0	0.827 (0.634–1.079)	0.161	0.06	0.813	0	0.908 (0.553–1.491)	0.730	0.00	0.956	0	0.824 (0.499–1.361)	0.450	0.90	0.342	0	0.825 (0.617–1.104)	0.196
	All	rs4148328 (T > C)	2	4.47	0.034	78	0.970 (0.638–1.476)	0.887	3.15	0.076	68	1.025 (0.634–1.658)	0.918	5.23	0.022	81	1.003 (0.509–1.973)	0.994	2.69	0.101	63	0.966 (0.685–1.361)	0.843
	All	rs3755319 (A > C)	2	0.36	0.551	0	1.258 (0.969–1.634)	0.084	0.01	0.932	0	0.637 (0.404–1.002)	0.051	0.02	0.882	0	0.737 (0.461–1.178)	0.203	0.06	0.813	0	1.454 (1.100–1.921)	0.009
	China	rs4148323 (G> A)	4	4.18	0.243	28	1.000 (0.791–1.265)	0.998	4.72	0.196	36	0.704 (0.347–1.426)	0.330	5.10	0.166	41	0.708 (0.333–1.505)	0.370	3.03	0.387	1	1.017 (0.842–1.227)	0.862
UGT2B7	China	rs7662029 (A > G)	2	0.06	0.813	0	2.371 (1.779–3.160)	<0.001	0.03	0.858	0	0.739 (0.444–1.231)	0.246	0.01	0.938	0	1.219 (0.715–2.077)	0.467	0.10	0.76	0	2.686 (1.988–3.627)	<0.001
	China	rs7439366 (T > C)	2	0.35	0.554	0	0.347 (0.238–0.506)	<0.001	0.00	0.950	0	0.675 (0.507–0.898)	0.007	0.11	0.739	0	0.338 (0.225–0.508)	<0.001	0.59	0.443	0	0.359 (0.238–0.540)	<0.001

UGT1A1, UDP-glucuronosyltransferase 1A1; UGT2B7, UDP-glucuronosyltransferase 2B7; AT-DILI, antituberculosis drug-induced liver injury; SNPs, single nucleotide polymorphisms; OR, odds ratio; 95% CI, 95% confidence interval.