Review Article
Systematic Review and Meta-Analysis of Congenital Toxoplasmosis Diagnosis: Advances and Challenges
Table 5
Summary estimates of diagnostic accuracy of molecular and bioassay techniques for the diagnosis of T. gondii infection.
| Parameter | PCR–AF | Bio–AF | PCR–PLA | Bio–PLA | Estimate | 2.5% CI | 97.5% CI | Estimate | 2.5% CI | 97.5% CI | Estimate | 2.5% CI | 97.5% CI | Estimate | 2.5% CI | 97.5% CI |
| Sensitivity | 0.851 | 0.695 | 0.934 | 0.574 | 0.416 | 0.718 | 0.589 | 0.585 | 0.593 | 0.586 | 0.472 | 0.692 | Specificity | 0.997 | 0.972 | 1.000 | 0.993 | 0.936 | 0.999 | 0.963 | 0.963 | 0.964 | 0.995 | 0.979 | 0.999 | Random effects correlation | −0.572 | | | 1.000 | | | −0.365 | | | −1.000 | | | Diagnostic odds ratio | 2018.385 | 228.652 | 17816.960 | 189.944 | 13.453 | 2681.756 | 37.706 | 36.843 | 38.588 | 258.867 | 69.775 | 960.405 | Likelihood ratio (LR+) | 302.048 | 30.916 | 2950.945 | 81.498 | 7.388 | 899.084 | 16.085 | 15.815 | 16.360 | 107.661 | 28.853 | 401.718 | Likelihood ratio (LR−) | 0.150 | 0.069 | 0.325 | 0.429 | 0.295 | 0.623 | 0.427 | 0.422 | 0.431 | 0.416 | 0.318 | 0.544 |
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PCR: polymerase chain reaction; AF: amniotic fluid; Bio: bioassay; PLA: placenta.
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