Challenges Associated with Tyrosine Kinase Inhibitor Therapy for Metastatic Thyroid Cancer

Table 2

Clinically significant CYP3A4 inducers, inhibitors, and substrates.

CYP3A4 inducers	CYP3A4 inhibitors	CYP3A4 substrates
Dexamethasone	Calcium channel blockers: amiodarone, verapamil	Statins: atorvastatin, lovastatin, and simvastatin (not pravastatin) (not rosuvastatin)
Anticonvulsants: phenytoin, carbamazepine	Azole antifungals: itraconazole, voriconazole, and ketoconazole	Calcium channel blockers: amlodipine, diltiazem, felodipine, nifedipine, and verapamil
Phenobarbital
Rifampin	Macrolide antibiotics: erythromycin, and clarithromycin (not azithromycin)
St. John’s wort
HIV antivirals: nonnucleoside reverse transcriptase inhibitors: efavirenz, and nevirapine	HIV antivirals: protease inhibitors: indinavir, nelfinavir, and ritonavir
Pioglitazone