Thyroid Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy: A Single Center Study

Table 1

Comparisons of clinical characteristics between controls, patients without DN, and patients with DN.

	Controls (n = 103)	Patients without DN (n = 100)	Patients with DN (n = 139)	p value
Gender (male/female)	55/58	54/46	76/63	0.601
Age (years)	56.8±12.5	58.5±8.9	59.1±8.9	0.211
Diabetic duration (years)	-	7.5±5.3	14.8±	< 0.001
Hypertension (%)	41.7	47.0		0.001
Smoking history (%)	31.1	36.0	43.2	0.148
Drinking history (%)	43.7	48.0	51.8	0.458
BMI (kg/)	23.4±2.9	26.6±	26.1±	< 0.001
Waist circumstance (cm)	96.3±5.6	95. 8±9.9	98.9±10.0	0.079
Hip circumstance (cm)	85.0±8.6	101.1±	98.5±	< 0.001
HbA1c (%)	5.3±0.5	8.1±	8.9±	< 0.001
SCr (mol/L)	67.5±17.6	57.0±12.2	228.0±	< 0.001
eGFR (mL/min⋅1.73 )	103.0 (92.2-116.5)	123.5	86.3	< 0.001
BUN (mmol/L)	5.3±1.3	5.5±1.4	11.9±	< 0.001
UACR (mg/g)	-	11.2 (6.9-16.0)	524.8	< 0.001
TC (mmol/L)	5.0±0.9	4.9±1.0	5.5±	0.010
TG (mmol/L)	1.4 (0.9-1.9)	1.7	1.8	< 0.001
HDL-C (mmol/L)	1.4±0.4	1.1±	1.1±	< 0.001
LDL-C (mmol/L)	3.1±0.8	3.1±1.0	3.3±1.3	0.370
TSH (mIU/L)	1.9 (1.3-2.6)	2.0 (1.2-3.0)	2. 7	< 0.001
FT3 (pmol/L)	5.2±0.5	4.8±	4.3±	< 0.001
FT4 (pmol/L)	15.4±1.8	15.2±2.1	14.9±2.2	0.125

DN, diabetic nephropathy; BMI, body mass index; HbA1c, glycosylated hemoglobin; SCr, serum creatinine; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen; UACR, urinary albumin-to-creatinine ratio; TC, total cholesterol; TG, serum triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. < 0.05, < 0.01 versus controls; < 0.05, < 0.01 versus patients without DN.