Clinical Study
Peripheral Regulatory Cells Immunophenotyping in Kidney Transplant Recipients with Different Clinical Profiles: A Cross-Sectional Study
Table 1
Demographic and clinical data of kidney transplant recipients.
| | | ELTGF () | CGD () |
| | Demographics | | | | Age at KT (years) | | | | Mean ± SD | 34.7 ± 11.6 | 34.0 ± 10.0 | | Range | (17–60) | (22–51) | | Current age (years) | | | | Mean ± SD | 56.0 ± 9.6 | 43.0 ± 11.0 | | Range | 43–70 | 31–60 | | Gender (female/male) | 8/6 | 1/8 | | Type of donor (LRD/ DD) | 12/2* | 7/2* | | Donor age at KTR (years) | | | | Mean ± SD | 32.9 ± 9.33 | 39.9 ± 13.0 | | Range | (19–50) | (20–61) | | Donor gender (female/male) | 7/7 | 8/1 |
| | Clinical | | | | Cause of ESRD | A = 8, B = 1, C = 1, D = 2, E = 1, F = 1 | A = 4, C = 1, D = 1, G = 2 | | Time elapsed since transplant (years) | | | | Mean ± SD | 21.3 ± 5.6 | 9.2 ± 2.4 | | Range | 7–30 | 4–12 | | Histocompatibility (Hap-match) | 2-Hap = 8; 1-Hap = 4; 0-Hap = 2 | 1-Hap = 5; 0-Hap = 4 | | Current immunosuppression regimen (patients) | AZA/PDN = 11 | CNI/MMF/PDN = 6
SRL/MMF/PDN = 3 | | Without immunosuppression (patients) | 3 | 0 |
| | Laboratory | | | | sCr 1 year post-KT, (mg/dL) | | | | Mean ± SD | 1.06 ± 0.39 | 1.75 ± 0.43 | | Range | 0.55–1.7 | 1.26–2.81 | | sCr current, (mg/dL) | | | | Mean ± SD | 0.90 ± 0.21 | 1.84 ± 0.21 | | Range | 0.55–1.20 | 1.57–2.26 | | 1 year post-KT eGFR (mL/min) | | | | Mean ± SD | 72.00 ± 25.7 | 47.00 ± 5.90 | | Range | 50–134 | 40–57 | | Current eGFR (mL/min) | | | | Mean ± SD | 79.00 ± 20.3 | 38.00 ± 7.23 | | Range | 60–126 | 23–48 | | ΔGFR = current – 1 year post-KT, (mL/min) | | | | Mean ± SD | 8.0 ± 32.4 | −9.00 ± 7.00 |
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HD: healthy donor, CGD: chronic graft dysfunction, ELTGF: excellent long-term graft function under immunosuppression, LRD: living related donor, DD: deceased donor, cause of ESRD: A: unknown, B: congenital, C: chronic UTI, D: Glomerulonephritis, E: Poststreptococcal glomerulonephritis, F: Nonsteroidal anti-inflammatory drugs, G: Diabetes Mellitus, sCr: serum creatinine, ESRD: end stage renal disease, eGFR: estimated glomerular filtration rate, AZA: azathioprine, PDN: prednisone, CNI: calcineurin inhibitor, MMF: mycophenolate mofetil, SRL: sirolimus.
*DD was assigned as “0-Haplotypes-match” because donor MHC typing was not available.
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