Exenatide Pretreatment Improved Graft Function in Nonhuman Primate Islet Recipients Compared to Treatment after Transplant Only
Figure 5
Paraffin-embedded liver sections from islet recipients stained for insulin (a, c, e, g) and CD3 (b, d, f, h), 20x magnification. Animals pre-treated with exenatide showed insulin-positive cells (a) with little evidence of CD3 positive cells (b) (day 435 posttransplant). Animals receiving exenatide after transplant only showed evidence of islet destruction with insulin accumulation in the Kupffer cells of the liver (c). CD3 positivity was also noted throughout the liver in animals treated with exenatide after transplant only (d) (day 10 posttransplant). Minimal evidence for insulin positive islet cells was found in the liver of animals treated with conventional immunosuppression while some residual staining was noted in Kupffer cells of these animals (e). Some CD3 positive cells were also noted in these grafts (f) (day 90 posttransplant). No insulin positivity (g) or CD3 positive cells (h) were found in the livers of untreated animals (day 10 posttransplant).
