Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis

Table 5

Univariate and multivariate analysis of factors associated with IF/TA grade II or III on central biopsy reading for surveillance and diagnostic biopsies. All factors on univariate analysis showing an association (𝑃<0.1) are shown in the table and were included in the multivariate analysis.

Univariate analysis
	IF/TA II or III (𝑁=38)	No IF/TA or IF/TA I (𝑁=86)	𝑃 value
Recipient gender, 𝑛 (%)
Male	17/71 (23.9)	54/71 (76.1)	0.06^a
Female	21/53 (39.6)	32/53 (60.4)
History of diabetes, 𝑛 (%)
Yes	6/8 (75.0)	2/8 (25.0)	0.010^b
No	32/116 (27.6)	84/116 (72.4)
Cold ischemia time, hours
<12 hours	2/22 (9.1)	20/22 (90.9)	0.016^a
≥12 hours	36/102 (35.3)	66/102 (64.7)
Donor age, 𝑛 (%)
<60 years	22/86 (25.6)	64/86 (74.4)	0.066^a
≥60 years	16/38 (42.1)	22/38 (57.9)
Delayed graft function, 𝑛 (%)
Yes	13/27 (48.1)	14/27 (51.9)	0.026^a
No	25/97 (25.8)	72/97 (74.2)
Biopsy-proven acute rejection prior to biopsy, 𝑛 (%)
Yes	8/16 (50.0)	8/16 (50.0)	0.086^b
No	30/108 (27.8)	78/108 (72.2)
eGFR at month 3, mL/min/1.73 m^2 c
<50	22/47 (46.8)	25/47 (53.2)	0.002^a
≥50	16/77 (20.8)	61/77 (79.2)
eGFR at month 6, mL/min/1.73 m^2 c
<50	25/50 (50.0)	25/50 (50.0)	<0.001^a
≥50	13/72 (18.1)	59/72 (81.9)
Missing	0	2
Multivariate analysis
	Odds ratio	95% CI	𝑃 value
eGFR at month 6, mL/min/1.73 m^2 c	3.85	1.64, 9.05	<0.002
<50 versus ≥50
History of diabetes	0.17	0.029; 0.98	0.05
No versus Yes
Cold ischemia time	0.18	0.036; 0.93	0.04
<12 h versus ≥12 h

IF/TA: interstitial fibrosis/tubular atrophy.
^aChi squared.
^bFisher.
^caMDRD formula.
Percentages are calculated based on the denominator in each row.