Efficacy and Safety of Low-Dose Everolimus as Maintenance Immunosuppression in Cardiac Transplant Recipients

Table 4

Time course of biochemical paramters in cardiac transplant recipients on low-dose EVL (LD) or high-dose EVL (RD).

Parameter	𝑇0	𝑇6	𝑇12	𝑃 value
	LD 𝑛=51; RD 𝑛=56	LD 𝑛=44; RD 𝑛=41	LD 𝑛=39; RD 𝑛=36
Creatinine (mg/dL)
LD group	2.23±0.75	2.06±0.87	2.05±0.79	0.030
RD group	2.06±0.44	2.07±0.83	2.08±0.84	0.725
BUN (mg/dL)
LD group	99±38	81±34	78±29	0.003
RD group	93±37	97±51	90±41	0.420
Triglycerides (mg/dL)
LD group	162±80	198±106	209±116	0.006
RD group	182±107	254±211	253±222	0.063
Total cholesterol (mg/dL)
LD group	206±54	216±62	222±51	0.029
RD group	199±50	228±63	229±56	0.013
HDL-cholesterol (mg/dL)
LD group	57.4±15.7	57.0±19.0	56.0±16.6	0.639
RD group	52.0±15.7	59.4±17.7	59.8±15.4	<0.001
LDL-cholesterol (mg/dL)
LD group	121±45	125±44	123±41	0.815
RD group	119±33	129±42	124±43	0.611
White blood cells (10^6/L)
LD group	7.58±3.40	6.60±1.89	6.36±2.04	0.202
RD group	7.23±1.77	7.20±1.57	7.11±1.78	0.268
Red blood cells (10^12/L)
LD group	4.11±0.61	4.32±0.64	4.48±0.74	<0.001
RD group	4.15±0.59	4.35±0.69	4.44±0.73	0.076
Platelets (10^9/L)
LD group	218±66	219±65	220±73	0.819
RD group	223±77	224±59	220±52	0.467