|
| Category | Remarks |
|
| Everolimus |
| All de novo heart transplant recipients except for those with special conditions and/or risks (see the following) |
Checking all patients for possibility of everolimus therapy due to its potential to reduce CNI-related toxicity, CMV infection, and malignancy risk and CAV |
|
| Everolimus only with special care |
| Specific risks for renal impairment or creatinine increase |
Reduceing CsA exposure to a minimum, monitoring urine electrophoresis and proteinuria, and stopping everolimus in the event of proteinuria > 1 g/day and/or signs of new glomerular damage on urine electrophoresis |
|
| Risks for wound healing disorders (diabetes mellitus, obese patients, high steroid exposure, and ventricular assist device) | Delay initiation of everolimus until completion of wound healing and resolution of any bacterial or fungal infection |
|
| Uncontrolled severe hyperlipidemia | Delay initiation of everolimus until serum lipids have been controlled
Always administer everolimus in combination with lipid-lowering therapy for example, fluvastatin |
|
| Everolimus not appropriate |
(i) Paracorporal biventricular assist device with immanent risk of infection
(ii) Infected ventricular assist device
(iii) LVAD in conjunction with specific risks such as combination of Thymoglobulin induction and infection | Avoid antilymphocyte antibodies for induction in patients with elevated risk for early postoperative infection
Everolimus may be initiated after completion of wound healing and resolution of any bacterial or fungal infection |
|
| Latent bacterial or fungal infections | Everolimus may be unsuitable in individual cases based on benefit/risk assessment |
|
| High probability of reoperation or necessity for additional surgery in the initial phase |
Considering late initiation of everolimus to avoid the need to switch immunosuppressive regimen during a critical period |
|
| GFR < 40 mL/min/1.73 m2 if slope shows an ongoing deterioration of renal function | Delay initiation of everolimus
Everolimus may be initiated if CNI exposure requires marked reduction |
|
