Risk-Adjusted Analysis of Relevant Outcome Drivers for Patients after More Than Two Kidney Transplants

Table 4

The univariate influences of the investigated variables on graft survival are shown (univariate Cox regression analysis).

Recipient variables	value	Hazard ratio	95% confidence interval
Recipient sex	0.604	n.a.	n.a.
Recipient blood group	0.562	n.a.	n.a.
Age in years at last transplantation	0.433	n.a.	n.a.
Number of kidney transplants	0.653	n.a.	n.a.
PRA max. in %	0.460	n.a.	n.a.
PRA max. in groups (0–30%, >30–70%, and >70%)	0.480	n.a.	n.a.
PRA at last transplant in %	0.412	n.a.	n.a.
PRA at last transplant in groups (0–30%, >30–70%, and >70%)	0.427	n.a.	n.a.
Number of HLA-DR mismatches	0.441	n.a.	n.a.
Number of all HLA mismatches	0.004	1.657	1.180–2.326
Number of all HLA mismatches in groups (0–2, 3–6)	0.002	4.440	1.691–11.655
Plasmapheresis (yes/no)	0.410	n.a.	n.a.
Induction therapy (yes/no)	0.334	n.a.	n.a.
Type of induction therapy	0.261	n.a.	n.a.
Cyclosporine versus tacrolimus based therapy	0.028	3.176	1.131–8.916
Mycophenolate mofetil versus azathioprine therapy	0.839	n.a.	n.a.
Living donor versus deceased donor	0.374	n.a.	n.a.
Simultaneous nephrectomy of previous graft (yes/no)	0.535	n.a.	n.a.
Number of previous operations at transplant site	0.463	n.a.	n.a.
Operating time in minutes	0.958	n.a.	n.a.
Cold ischemic time in minutes	0.914	n.a.	n.a.
Surgical complications (yes/no)	0.059	n.a.	n.a.
Number of surgical complications	0.003	2.225	1.318–3.758
Reoperation due to a complication (yes/no)	0.026	3.013	1.144–7.939
Primary graft nonfunction (yes/no)	<0.001	6.384	2.290–17.797
Acute graft rejection episodes (yes/no)	0.005	4.872	1.602–14.816
Chronic graft rejection (yes/no)	0.888	n.a.	n.a.