Time to Relapse and Relapse Predictors in Patients with Schizophrenia at Ayder Comprehensive Specialized Hospital, Northern Ethiopia
Table 5
Cox regression analysis for predictors of relapse among patients with schizophrenia ().
Predictors
Univariate model CHR [95% CI], value
Multivariate model AHR [95% CI], value
Age at first admission (year)
0.69 (0.33–2.83), 0.135
0.65 (0.34-0.88), 0.041
Sex of the patients
0.950
Male
1.00
Female
0.98 (0.63-1.54)
Residence
0.406
Urban
1.00
Rural
1.20 (0.77-1.88)
Religion
0.320
Orthodox
1.00
Muslim
0.55 (0.28-1.07)
Others
1.48 (0.46-4.76)
Marital status
0.009
Single
1.00
1
Married
1.20 (0.75-2.14)
1.76 (0.97-3.20), 0.060
Divorced
2.03 (1.18-3.50)
2.50 (1.18–5.28), 0.016
Widowed
2.33 (0.55-9.91)
2.53 (0.40-16.05), 0.323
Occupational status
0.890
Employed
1.00
Nonemployed
1.01 (0.57–1.86)
Private job
0.91 (0.37–2.24)
Educational status
0.858
Unable to read and write
1.00
Primary
0.98 (0.46–2.11)
Secondary
0.76 (0.35-1.65)
College and above
0.99 (0.46–2.15)
Living conditions
0.438
With family
1.00
Living alone
0.76 (0.38–1.52)
Stressful life events
0.116
Yes
1.00
No
0.75 (0.45-1.09)
Suicidal attempt
0.006
Yes
1.00
1
No
0.54 (0.35-0.84)
0.72 (0.44–1.19), 0.202
Substance misuse
0.020
Yes
1.67 (1.08-2.63), 1.00
1.8 (1.01–3.22), 0.021
No
1.00
Duration of 1st hospitalization (days)
0.73 (0.23-0.98), 0.046
0.69 (0.57, 0.86), 0.011
Treatment adherence
0.001
Adhered
1.00
1
Not adhered
5.5 (3.00–9.97)
5.7 (3.03–10.74), 0.001
History of comorbid depression
0.019
Yes
1.00
1.00
No
0.57 (0.36–0.91)
0.92 (0.52–1.66)), 0.786
History of discharge with any medical illness
0.045
Yes
1
1
No
0.62 (0.41–0.99)
0.77 (0.46–1.30), 0.337
Family history of psychiatric illness
0.595
Yes
1
No
0.86 (0.48-1.50)
Note: AHR: adjusted hazard ratio; CHR: crude hazard ratio; 1.00: reference. Predictors with value < 0.25 in univariate analyses were considered for multivariate analysis. Significant at 5% level of significance in the multivariate model.
