Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies

Figure 2

FET PET combined with DWI in recurrent glioblastoma (histologically confirmed). (a) Axial postcontrast T1-weighted MRI, green: gross total volume (GTV). (b) Axial FET PET, yellow: GTV on PET. (c) ADC map, red: GTV by ADC (low), corresponding to a hyperintensity in (d) DWI-MRI. (e) Illustration of all three volumes on planning CT. (f) Dose distribution of the treatment plan based on FET PET. The volumetric comparison thus revealed that the majority of the GTVs-ADC (low) is located outside areas of contrast enhancement in postcontrast T1-weighted MRI (mean nonoverlapping volume , median 72.2%, and range 5.8–100%) and also outside areas of increased FET uptake (mean nonoverlapping volume , median , and range 12.3–385.1% in the total cohort, ). Reproduced with permission from Figure 3 in Popp et al. [47].

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