Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies

Figure 7

Spatial mismatch between AMT PET uptake and relative cerebral blood volume (CBV) on PWI. Examples of ¹¹C-alpha-methyl-L-tryptophan (AMT) and relative cerebral blood volume (rCBV) mismatch in patients with newly diagnosed (a) and recurrent (b) glioblastoma. (a) In patient #6, high AMT uptake (AMT tumor to normal [T/N] ratio: 2.78) was associated with low rCBV values (T/N ratio: 0.88) (red circles) adjacent to the contrast-enhancing tumor mass (blue dashed circles). (b) In patient #15, low AMT uptake (T/N ratio: 0.54) was associated with increased rCBV values (T/N ratio: 1.60) in the extensive fluid-attenuated inversion recovery (FLAIR) hyperintense area surrounding the contrast-enhancing tumor mass with high-AMT uptake (yellow circle). The color bar shows a relative scale (0%-100%). Reproduced with permission from Figure 3 of John et al. [62].