Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies

Table 2

Summary of aaPET with PWI studies.

Study	Year	Study location	No. of patients	aaPET	PWI	Tumor type	Main results
Beppu et al. [56]	2019	Morioka, Japan	24	MET	ASL	Recurrent GBM	Modalities were significantly correlated before and after treatment. ASL PWI reliably predicted survival, but MET PET was more accurate.
Pala et al. [57]	2019	Günzburg, Germany	18	MET	DSC	GBM	MET PET is more sensitive than PWI DSC for residual tumor detection. PWI DSC cannot substitute MET PET in tumor detection.
Qiao et al. [58]	2019	Beijing, China	42	MET	DSC	High-grade glioma	Both could accurately differentiate radiation injury from recurrence. Combined, they yielded the best accuracy.
Roodakker et al. [39]	2019	Uppsala, Sweden	4	MET	DSC	Oligodendroglioma	MET PET could identify tumor cell density, but PWI DSC could not. The modalities were not significantly correlated.
Lundemann et al. [49]	2019	Copenhagen, Denmark	16	FET	DCE	Pretreatment GBM	FET PET had the highest predictive value for recurrence. Combined parameters could map the probability of recurrence.
Dissaux et al. [59]	2020	Brest, France	30	FET	DSC	High-grade glioma	PWI DSC is highly correlated with standard MRI, but FET PET provides complementary data.
Verburg et al. [52]	2020	Amsterdam, Netherlands	20	FET	ASL, DSC	Newly diagnosed nonenhancing glioma	FET PET with PWI DSC together could diagnose IDH-mutant glioma.
Schon et al. [60]	2020	Munich, Germany	46	FET	DSC	Newly diagnosed glioma	Both modalities could identify vascularity, but only FET PET could identify cellularity.
Fraioli et al. [61]	2020	London, UK	40	FDOPA	DSC	Glioma	Both could differentiate tumor, but performed better when combined. FDOPA PET distinguished more features.
Tatekawa et al. [53]	2020	Los Angeles, USA	61	FDOPA	DSC	Treatment-naïve glioma	Positively correlated in IDH-wt and IDH-mutant-1p/19q-non-codeleted. Not correlated in IDH-mutant-codeleted.
John et al. [62]	2019	Detroit, USA	20	AMT	DSC	GBM	Moderate correlation between modalities in nonenhancing tumor regions.