Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies

Table 3

Summary of aaPET with MRS studies.

Study	Year	Study location	No. of patients	aaPET	MRS	Tumor type	Main results
Kudulaiti et al. [63]	2019	Shanghai, China	109	MET	CNI	Nonenhancing supratentorial glioma	MET PET was more sensitive and specific than MRS, and when combined, sensitivity was higher and specificity stable.
Kebir et al. [64]	2019	Essen, Germany	19	MET	NAA, Cho, Cr	Newly diagnosed glioma	Both have limited potential in glioma subtyping. MET PET is better for differentiating IDH status and MRS for glioma subgrouping.
Lundemann et al. [49]	2019	Copenhagen, Denmark	16	FET	3D MRSI	Glioblastoma	FET PET had the highest predictive value for recurrence. 3D MRSI was of insufficient quality for analysis.
Verburg et al. [52]	2020	Amsterdam, Netherlands	20	FET	CNI	Newly diagnosed nonenhancing glioma	FET PET combined with other modalities detects glioma infiltration better than standard MRI or FET PET. MRS data is insufficient due to limited sampling ability.
Piccardo et al. [54]	2019	Genoa, Italy	22	FDOPA	CNI, Cho/Cr, lactate	Pediatric DMG	Both could differentiate tumor grade and H3K27M mutation, but only FDOPA PET could do so independently of histology.

Cho: choline; Cr: creatine; CNI: choline-to-N-acetylaspartate index; NAA: N-acetylaspartate.