PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to <i>S. aureus</i> Infection

<div>MicroPET imaging of S1PR1 activity in <i>S aureus</i>-infected mice. (a) Radiosynthesis of S1PR1-specific radiotracer, [<sup>18</sup>F]TZ4877; (b) representative sagittal microPET images of [<sup>18</sup>F]TZ4877 in mice. Comparing with sham mice, the tracer uptake was significantly higher in the infected mice, and the increased uptake of the tracer showed <i>S aureus</i> dose dependent; (c) the tracer uptake in the brain was quantified; time-activity curves showed that the tracer uptake in infected mice was significantly higher than mice without infections; (d) the average tracer uptake in the brain from 30 to 50 min of the PET scan showed a dose-dependent manner. 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Molecular Imaging

fig1

Figure 1

Figure 1: PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to <i>S. aureus</i> Infection 

Molecular Imaging

PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection

Figure 1