Research Article

Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using 99mTc-MAG3-Cet-F(ab)2-Based SPECT/CT Imaging

Figure 6

In vitro biodistribution and SPECT/CT imaging. (a) Biodistribution assay demonstrating that 99mTc-MAG3-Cet-F(ab)2 uptake in MGC803 tumors peaked at 16 h after injection. (b) 99mTc-MAG3-Cet-F(ab)2 SPECT/CT imaging showing significant different radionuclide uptake between an MGC803 tumor and a HT29 tumor (arrow). (c) Immunofluorescence showing the higher EGFR expression in MGC803 tumor slices compared with HT29 tumor slices. (d) Relationship between SPECT/CT image and immunofluorescence.
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