Evaluation of Intraperitoneal [¹⁸F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity

Figure 5

The effect of subchronic ketamine administration on dopamine synthesis capacity measured by two different routes of [¹⁸F]-FDOPA administration. (a, b) calculated using (a) 20-140 minutes of the TAC and extended Patlak analysis following i.p. administration or (b) 15-120 minutes of the TAC following i.v. administration of [¹⁸F]-FDOPA in naïve (Ctrl) or ketamine-treated (KET) animals. Values are ; (Ctrl, i.p.; KET, i.p.; KET, i.v.) or (Ctrl, i.v.); , , unpaired two-tailed -tests. (c) SUVR over time in Ctrl or KET animals and following i.p. administration of [¹⁸F]-FDOPA. Dashed lines show the best-fit linear regression. Values are

(a)

(b)

(c)