89Zr Immuno-PET Imaging of Tumor PD-1 Reveals That PMA Upregulates Lymphoma PD-1 through NFκB and JNK Signaling

<div>In vivo pharmacokinetics and biodistribution. (a) Time-dependent blood clearance of 89Zr-PD-1 IgG following intravenous injection into normal Balb/C mice. Curve fitting by two-phase decay shows biexponential blood clearance that derives pharmacokinetic parameters of early and late rate constants (K1 and K2) and half-lives (T1/2α and T1/2β). (b) Biodistribution of 89Zr-PD-1 IgG in normal Balb/C mice at 5 days after intravenous injection.</div>

Molecular Imaging

fig2

Figure 2

Figure 2: 89Zr Immuno-PET Imaging of Tumor PD-1 Reveals That PMA Upregulates Lymphoma PD-1 through NFκB and JNK Signaling