In Vivo Distribution and Therapeutic Efficacy of Radioiodine-Labeled pH-Low Insertion Peptide Variant 3 in a Mouse Model of Breast Cancer

Figure 5

Therapeutic efficacy of ¹³¹I-labeled variant 3 pH-low insertion peptide (Var3-pHLIP) in mice-bearing MDA-MB-231 xenografts. (a) Images of MDA-MB-231 xenografts in the four study groups ( for each group) at the end of treatment. (b) The relative tumor volume in MDA-MB-231 xenografts was significantly lower in the ¹³¹I-Var3-pHLIP-treated group () than in the groups treated with Var3-pHLIP (, ), ¹³¹I (, ), and saline (, ) at the end of treatment. The asterisk indicates that value is less than 0.05. (c) There was no significant difference in body weight among the groups. Data are .

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