Pattern of F-18 FDG Uptake in Colon Cancer after Bacterial Cancer Therapy Using Engineered Salmonella Typhimurium: A Preliminary In Vivo Study

Figure 3

Changes in tumor volume and FDG uptake after bacterial cancer therapy (BCT) with engineered Salmonella typhimurium in a CT26 colon cancer cell line mouse model. Changes in tumor growth ratios (a), normalized tumor volume change (b), SUVmax (c), SUVmean (d), SUVmax% (e), and SUVmean% (f). Each point in the graphs represents a data measurement at that time point. (a) The tumor growth ratio was calculated as the measured volume divided by the initial volume (0 dpi). (b) Normalized volume change is calculated using (c, d) Changes in FDG uptake in the tumor are shown as SUVmax in (c) and SUVmean in (d). (e, f) Percent changes in FDG uptake are shown as SUVmax% in (e) and SUVmean% in (f). SUVmax% and SUVmean% are calculated as . Abbreviations: FDG, 2-deoxy-2[¹⁸F]fluoro-D-glucose; dpi, days post-injection; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value.

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