Pattern of F-18 FDG Uptake in Colon Cancer after Bacterial Cancer Therapy Using Engineered Salmonella Typhimurium: A Preliminary In Vivo Study

Figure 4

Correlations between treatment responses and pretreatment tumor FDG uptake in the CT26 colon cancer cell line mouse model. FDG uptake was measured as SUVmax and SUVmean. Data at 0 dpi were presented as mean data before BCT. Treatment responses were determined at two time points: early (6 dpi) and late (16 or 17 dpi). Normalized volume change is calculated using . (a) Tumor SUVmax at 0 dpi and normalized volume change (6 dpi). (b) Tumor SUVmean at 0 dpi and normalized volume change (6 dpi). (c) SUVmax at 0 dpi and normalized volume change at 16 or 17 dpi. (d) SUVmean at 0 dpi and normalized volume change at 16 or 17 dpi. Footnote: Of the 11 mice, two died during studies; A5 at 2 dpi and A3 at 16 dpi (size measurements were performed until 12 dpi). Therefore, the number of mice for (a) and (b) was 10 and for (c) and (d), 9. Abbreviations: FDG, 2-deoxy-2[¹⁸F]fluoro-D-glucose; dpi, days post-injection; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value.

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