Pattern of F-18 FDG Uptake in Colon Cancer after Bacterial Cancer Therapy Using Engineered Salmonella Typhimurium: A Preliminary In Vivo Study

Figure 5

Correlations between treatment responses and early FDG uptake changes after bacterial cancer therapy (BCT) using engineered Salmonella typhimurium in a CT26 colon cancer cell line mouse model. Treatment responses were determined at two time points: early (6 dpi) and late (16 or 17 dpi). Normalized tumor volume change is calculated using . Early SUV reduction% was defined as at 0 dpi. A higher early SUV reduction% meant a larger decrease in FDG uptake after BCT (1 or 2 dpi). (a) Early SUVmax reduction% and normalized volume change at 6 dpi. (b) Early SUVmean reduction% and normalized volume change at 6 dpi. (c) Early SUVmax reduction% and normalized volume change at 16 or 17 dpi. (d) Early SUVmean reduction% and normalized volume change at 16 or 17 dpi. Abbreviations: FDG, 2-deoxy-2[¹⁸F]fluoro-D-glucose; dpi, days post-injection; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value; early SUVmax reduction%, at 0 dpi; early SUVmean reduction%, at 0 dpi.

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