Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318

Figure 7

(a) Representative images of H&E and IHC stained sections (CD45, Iba1, and Siglec-15) from 624-MEL+S15, LOX IMIV, HCC-827, and 624-MEL WT tumors. (b) Comparison of individual tumor necrosis (%; estimated from H&E staining) and vessel density (estimated from CD-31 IHC staining) for the 4 tumor types. (c) IHC quantitative analysis of Siglec-15 expression levels (staining intensity score and -score) and the number of positive cells per mm² for CD45 and Iba1 of the tumor types; each bar represents the (, 624-MEL+S15 tumors; , LOX IMIV, HCC-827, and 624-MEL WT tumors).

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