Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Figure 6

MPI studies are comparable to ^99mTc-sulfur colloids and ¹¹¹In RBC scintigraphy studies. (a, b) MPI images overlaid on an X-ray CT image for anatomical reference at 10 minutes post i.v. administration of carboxydextran-coated SPIO, Ferucarbotran, and polyethylene glycol (PEG)-coated long-circulating SPIO of LodeSpin, respectively. Ferucarbotran has a shorter blood half-life and is rapidly taken up by the liver, similar to sulfur colloid tracers (c). On the other hand, PEG-coated SPIOs show a longer blood circulation time of about 4.2 hours and are useful in perfusion studies similar to ¹¹¹Inlabeled red blood cell scintigraphy but without any radiation. (Image reproduced with permission from Kesleman et al., Phys Med Biol. 2017) [30].

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