First-in-Human PET Imaging of [¹⁸F]SDM-4MP3: A Cautionary Tale

Table 2

estimates from all four [¹⁸F]SDM-4MP3 and [¹⁸F]SynVesT-1 participants in selected ROIs. Values are followed by SE (%) from fitting of 1-TCM.

ROI	[^18F]SDM-4MP3 VT		[^18F]SynVesT-1 VT
	P1	P2	P3	P4
Putamen	2.0 (1.3%)	2.1 (3.4%)	16.1 (0.5%)	22.23 (4.7%)
Cerebellum	1.6 (1.4%)	1.8 (3.7(%)	13.1 (0.7%)	16.3 (4.9%)
Frontal cortex	1.8 (1.6%)	1.9 (3.4%)	15.4 (0.4%)	18.3 (5.1%)
Hippocampus	1.8 (1.4%)	1.8 (3.4%)	14.9 (0.6%)	17.0 (6.2%)
Centrum semiovale	1.6 (1.8%)	1.7 (2.0%)	2.9 (1.4%)	3.5 (7.7%)