Modeling and Simulation of VEGF Receptors Recruitment in Angiogenesis

Figure 5

Time evolution of the overall amount of bound VEGFR2-gremlin complex on the membrane compared with fluorescence intensity from of the overall VEGFR2 (free and bound) in contact the substrate. The continuous lines correspond to the numerical simulation data, while points and error bars refer to the experimental data. To allow the comparison, both sets of data have been normalized to the respective values they reach at the final time s. The depletion of free receptors is clearly visible, whereas the sum of complex and free receptors concentration remains constant. Mass is therefore conserved in our numerical validation.