Phosphorylated Neurofilament Heavy Chain Correlations to Visual Function, Optical Coherence Tomography, and Treatment

Table 3

MS characteristics.

	Diagnosis of MS					All
	Baseline, 𝑁=17	Month 6, 𝑁=11	Year 5, 𝑁=44	Year 10, 𝑁=14	Year 15, 𝑁=9	𝑁=95
Mean (SD) EDSS
Year 5	1.97 (1.59)	1.77 (1.82)	1.30 (0.98)	0.71 (1.09)*	0.22 (0.44)**	1.28 (1.29)
Year 10	2.79 (1.88)	1.96 (1.96)	2.42 (2.41)	2.35 (2.13)	0.78 (0.79)***	2.24 (2.14)
Year 15	3.83 (1.90)	2.55 (1.62)	2.94 (2.46)	2.96 (2.12)	1.33 (1.36)	2.84 (2.18)
Year 5 mean (SD) sqrt pNFH
IV	0.29 (0.04)	0.24 (0.11)	0.25 (0.11)	0.33 (0.09)	0.22 (0.05)	0.26 (0.09)
Prednisone	0.45 (0.13)	0.36 (0.20)	0.33 (0.16)	0.31 (0.07)	0.41 (0.36)	0.37 (0.17)
Placebo	0.20 (0.13)	0.21 (0.20)	0.46 (0.34)	0.30 (0.06)	0.34 (0.11)	0.36 (0.27)
	𝑃=.008	𝑃=.52	𝑃=.065	𝑃=.85	𝑃=.52	𝑃=.041
≥5 MRI lesions at baseline	13 (77%)	3 (30%)	16 (42%)	4 (29%)	4 (57%)	40 (47%)
Year 15 mean (SD) RNFL	𝑁=2	𝑁=3	𝑁=8	𝑁=3	𝑁=4	𝑁=20
Affected eye	79.4 (4.6)	70.0 (8.1)	69.7 (19.8)	65.0 (17.0)	66.0 (25.5)	69.3 (17.4)
Fellow eye	94.6 (3.8)	74.2 (16.3)	82.0 (19.0)	97.3 (2.7)	73.1 (24.5)	82.6 (18.3)
Difference	15.2 (0.8)	4.2 (8.5)	12.4 (16.4)	32.3 (15.1)	7.1 (6.5)	13.3 (14.7)
Year 15 mean (SD) macular volume
Affected eye	7.1 (0.9)	6.1 (0.7)	6.0 (0.5)	6.8 (0.5)	6.2 (0.6)	6.3 (0.6)
Fellow eye	7.6 (0.1)	6.2 (0.8)	6.6 (0.6)	7.3 (0.9)	6.7 (0.7)	6.7 (0.7)
Difference	0.5 (0.8)	0.1 (0.2)	0.6 (0.5)	0.5 (0.4)	0.2 (0.2)	0.4 (0.4)