Research Article
The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis
Table 1
Patient characteristics: patients with MS Only compared to Patients with MS & Depression.
| Characteristic |
MS Only () |
MS & Depression () | statistic | value | | % | | % |
| Characteristics matched on | | | | | | | Age | | | | | N/A | N/A | <35 | 54 | 12.39 | 54 | 12.39 | | | 35–44 | 107 | 24.54 | 107 | 24.54 | | | 45–54 | 171 | 39.22 | 171 | 39.22 | | | 55–64 | 95 | 21.79 | 95 | 21.79 | | | 65+ | 9 | 2.06 | 9 | 2.06 | | | Sex | | | | | N/A | N/A | Male | 55 | 12.61 | 55 | 12.61 | | | Female | 381 | 87.39 | 381 | 87.39 | | | Region | | | | | N/A | N/A | Northeast | 53 | 12.16 | 53 | 12.16 | | | North Central | 124 | 28.44 | 124 | 28.44 | | | South | 166 | 38.07 | 166 | 38.07 | | | West | 93 | 21.10 | 93 | 21.10 | | | Unknown | 1 | 0.23 | 1 | 0.23 | | | Year of index date | | | | | N/A | N/A | 2004 | 66 | 15.14 | 66 | 15.14 | | | 2005 | 109 | 25.00 | 109 | 25.00 | | | 2006 | 109 | 25.00 | 109 | 25.00 | | | 2007 | 129 | 29.59 | 129 | 29.59 | | | 2008 | 23 | 5.28 | 23 | 5.28 | | | ITT DMT | | | | | N/A | N/A | Avonex | 97 | 22.25 | 97 | 22.25 | | | Betaseron | 51 | 11.70 | 51 | 11.70 | | | Copaxone | 198 | 45.41 | 198 | 45.41 | | | Rebif | 78 | 17.89 | 78 | 17.89 | | | Tysabri | 12 | 2.75 | 12 | 2.75 | | |
| Other characteristics | | | | | | | Insurance status | | | | | | | Comprehensive | 58 | 13.30 | 43 | 9.86 | 2.52 | 0.112 | Health maintenance org | 80 | 18.35 | 90 | 20.64 | 0.73 | 0.393 | Point-of-service | 99 | 22.71 | 58 | 13.30 | 13.06 | <0.001 | Preferred provider org | 191 | 43.81 | 226 | 51.83 | 5.63 | 0.018 | Other | 8 | 1.83 | 19 | 4.36 | 4.63 | 0.032 | Copayment with ITT drug | 370 | 84.86 | 340 | 77.98 | 6.82 | 0.009 | Mail order for ITT drug | 145 | 33.26 | 119 | 27.29 | 3.67 | 0.055 | Preperiod Charlson score | | | | | | | 0 | 331 | 75.92 | 271 | 61.16 | 19.31 | <0.001 | 1-2 | 93 | 21.33 | 132 | 30.28 | 9.11 | 0.003 | 3+ | 12 | 2.75 | 33 | 7.57 | 10.33 | <0.001 | Preperiod disability proxies | | | | | | | Muscoloskeletal | 181 | 41.51 | 262 | 60.09 | 30.10 | <0.001 | Medical | 137 | 31.42 | 210 | 48.17 | 25.51 | <0.001 |
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