The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis
Table 4
Ordinary least squares regression results dependent variable: MPR.
Variable
MS Only versus MS & Depression
Dx Depression versus Dx & Rx Depression
Rx Depression- ≥6 Mo Antidepressants versus <6 Mo
Coeff
value
Coeff
value
Coeff
value
Intercept
0.71
<0.001
0.64
0.047
0.47
<0.001
Insurance typea
HMO
−0.10
0.022
−0.14
0.509
-0.16
0.200
POS
−0.02
0.665
−0.07
0.731
0.02
0.901
PPO
0.01
0.890
0.12
0.491
0.02
0.860
Other
−0.002
0.974
−0.27
0.523
0.08
0.693
Medication dispensing
Copayment
0.06
0.047
−0.06
0.680
0.10
0.213
Mail order
0.05
0.051
0.02
0.909
0.08
0.216
Preperiod Charlson scoreb
1-2
0.01
0.738
0.09
0.521
0.06
0.379
3+
−0.04
0.467
0.04
0.853
0.09
0.422
Preperiod ADL proxies
Musculoskeletal
0.02
0.440
−0.03
0.828
0.06
0.294
Medical
0.02
0.448
0.10
0.419
−0.01
0.889
Preperiod depression
Any
−0.10c
<0.001
—
—
—
—
Dx & Rx
—
—
0.07d
0.518
—
—
Rx for at least 6 months
—
—
—
—
0.12e
0.049
Adjusted
0.05
0.08
0.06
aReference group: Comprehensive insurance.
bReference group: Charlson score of 0.
cReference group: patients with MS and no diagnosis of depression or receipt of an antidepressant.
dReference group: patients diagnosed with depression who did not receive an antidepressant.
eReference group: patients diagnosed with depression who were treated with an antidepressant for less than 6 months.