Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years: A Longitudinal Study
Table 2
Changes in MRI outcomes over 2 years between different study groups.
Total () mean (SD) median
Early group () mean (SD) median
Late group () mean (SD) median
value*
% Change in WBV (0-1 years)
−1.59 (3.9) −1.32***
−2.11 (3.5) −1.84***
−1.39 (4.1) −1.1***
0.531
% Change in WBV (1-2 years)
0.12 (5.3) −0.34
0.05 (3.4) −0.35
0.15 (5.9) −0.23
0.428
% Change in WBV (0–2 years)
−1.61 (3) −.37***
−2.23 (2.8) −2.2***
−1.37 (3.1) −0.98***
0.751
% Change in CV (0-1 years)
−2.15 (4.3) 1.78***
−2.31 (3.5) −1.88***
−2.1 (4.6) −1.77***
0.559
% Change in CV (1-2 years)
−0.01 (6.9) −0.09
−0.53 (4.7) −1.36
0.21 (6.6) −0.06
0.140
% Change in CV (0–2 years)
−2.22 (4) −2.28***
−2.48 (4) −2.98***
−2.12 (4) −1.98***
0.606
% Change in T2-LV (0-1 years)
9.3 (43.6) 5.6*
11.8 (48.5) 9
8.8 (40.6) 4.7
0.442
% Change in T2-LV (1-2 years)
28.1 (47.6) 19.5***
38.6 (47.7) 29.5***
24 (47) 16.1***
0.091
% Change in T2-LV (0–2 years)
33.9 (52.8) 24.4***
48.3 (57.5) 41.8***
28.3 (49.9) 19.8***
0.015
WBV: whole brain volume, CV: cortical volume, and LV: lesion volume. Statistical differences between the early and late disease duration groups ( value*) were calculated using Student’s -test. The Wilcoxon signed-rank test was used to test within group % changes of the paired measures involving the baseline and the followup indices (***, **, and *).
