Multiple Sclerosis International / 2015 / Article / Tab 2 / Research Article
Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials Table 2 Cross-sectional comparison of retinal layer thickness between Spectralis and Cirrus HD-OCT.
Layer Average thickness (SD) (μ m) Mean difference (95% CI) (μ m) Upper LOA (95% CI) (μ m) Lower LOA (95% CI) (μ m) mRNFL 32.35 (4.38) 4.71 (4.45 to 4.97) 8.22 (7.77, 8.68) 1.20 (0.74, 1.65) GCIP 65.59 (8.13) 0.26 (0.04 to 0.48) 3.17 (2.79, 3.55) −2.65 (−3.03, −2.27) INL 35.59 (1.81) −1.31 (−1.43 to −1.12) 0.20 (0.01, 0.40) −2.83 (−3.03, −2.63) INL + OPL 60.59 (3.31) −1.09 (−1.33 to −0.86) 2.02 (1.62, 2.43) −4.21 (−4.62, −3.81) ONL 63.10 (5.80) −2.16 (−2.35, −1.97) 0.39 (0.05, 0.72) −4.71 (−5.05, −4.38) ONL + PR 108.56 (7.14) 0.20 (−0.05 to 0.46) 3.61 (3.17, 4.05) −3.20 (−3.65, −2.76) RPE 33.32 (1.92) 0.14 (−0.06 to 0.35) 2.92 (2.56, 3.28) −2.63 (−2.99, −2.27)
Average of thickness values derived from both OCT platforms. mRNFL: macular retinal nerve fiber layer; GCIP: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; INL + OPL: inner nuclear layer + outer plexiform layer; ONL: outer nuclear layer; ONL + PR: outer nuclear layer + photoreceptor segments; RPE: retinal pigment epithelium.