Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis

Table 4

Comparison of free light chains levels in CSF and free light chain indices in different patient groups.

Characteristic	MS	CIS	Other inflammatory diseases	Noninflammatory diseases
KFLC (mg/l) in CSF, median (IQ range)	9.1 (3.2–19.0)	7.3 (1.4–15.2)	2.3 (1.1–3.4)	1.3 (1.1–4.0)	0.002
KFLC index, median (IQ range)	22.4 (11.4–34.9)	17.4 (3.7–34.8)	1.9 (1.3–2.4)	1.8 (1.5–2.2)	<0.001
LFLC (mg/l) in CSF, median (IQ range)	5.6 (2.2–9.3)	4.5 (2.3–11.2)	3.2 (1.1–5.7)	4.7 (2.1–6.2)	0.56
LFLC index, median (IQ range)	7.5 (3.5–12.9)	5.9 (3.8–16.0)	2.5 (1.6–2.9)	2.8 (1.7–4.1)	<0.001

KFLC, kappa free light chain; LFLC, lambda free light chain; LR, likelihood ratio.