Research Article

The Role of G L U K 𝟓 -Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations

Figure 4

Activation of GLUK5-containing KARs can induce gamma frequency oscillations in the MEC. (a) Extracellular field recordings showing 1 second epochs of activity in a control setting (i) following application of 1 μM, (ii) 2 μM (iii), and 5 μM ATPA (iv). (b) Pooled line graphs (n = 10) demonstrating the effects of varying ATPA concentration on (i) frequency, (ii) area power, and (iii) peak amplitude of gamma oscillations in the MEC. Scale bar represents 200 milliseconds and 100 μV.
401645.fig.004a
(a)
401645.fig.004b
(b)