Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices

Figure 6

Working model of NVP-induced Tau phosphorylation. Blockade of NR2A-containing receptors appears to initiate the insertion of new functional NMDA receptors containing a high proportion of NR2B subunits in neuronal plasma membranes, promoting calcium accumulation. Through an unknown mechanism, Cdk5 activity would selectively enhance the phosphorylation of Ser199 residue in the proline-rich domain of Tau. In parallel, blockade of NR2A-containing receptors may reduce specific phosphatase activity which could have an impact on Tau phosphorylation at Ser199.